Wenzel B E, Peters A, Zubaschev I
Cell & Immunobiological Laboratory, Medical University, Lübeck, Germany.
Exp Clin Endocrinol Diabetes. 1996;104 Suppl 4:75-8. doi: 10.1055/s-0029-1211707.
There is now substantial evidence that autoimmune thyroid diseases (AITD) coincide with a subclinical persisting infection with Yersinia enterocolitica (YE) which manifests through humoral and cellular immune reactions against YE at the onset of AITD. The humoral and cellular crossreactivities of YE with thyroid autoantigens are exclusively directed against conformational epitopes of YE membrane associated antigens and of YE plasmid encoded virulence proteins (YOPs). Especially, the outer membrane domain of the TSH-Receptor (THSR) appears to have conformational homologies with YE antigens. Immunological- and molecular findings, however, do not allow definite conclusions about a potential role of YE-infection in AITD, although the evidence is suggestive. Recent investigations on the effect of YE-superantigen (Sag) on T-cells from patients with AITD as well as AITD like manifestations in YE immunized mice and rats may yield more conclusive information about the role of YE infection in the pathogenesis of AITD.
现在有大量证据表明，自身免疫性甲状腺疾病（AITD）与小肠结肠炎耶尔森菌（YE）的亚临床持续性感染同时存在，这种感染在AITD发病时通过针对YE的体液免疫和细胞免疫反应表现出来。YE与甲状腺自身抗原的体液和细胞交叉反应仅针对YE膜相关抗原和YE质粒编码的毒力蛋白（YOPs）的构象表位。特别是，促甲状腺激素受体（THSR）的外膜结构域似乎与YE抗原具有构象同源性。然而，尽管有证据提示，但免疫和分子研究结果尚不能就YE感染在AITD中的潜在作用得出明确结论。最近关于YE超抗原（Sag）对AITD患者T细胞的影响以及在YE免疫的小鼠和大鼠中出现的类似AITD表现的研究，可能会提供更多关于YE感染在AITD发病机制中作用的确切信息。
