Constantinescu C S, Hilliard B, Lavi E, Ventura E, Venkatesh V, Rostami A
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104-4283, USA.
J Neurol Sci. 1996 Nov;143(1-2):14-8. doi: 10.1016/s0022-510x(96)00195-5.
Phosphodiesterase inhibitor pentoxifylline (POX) has been shown to have multiple immunomodulatory effects in vitro and in vivo. It inhibits T cell proliferation, T helper 1-type cytokines, and tumor necrosis factor. We postulated that POX might have an in vivo immunomodulatory effect on a T-cell-mediated autoimmune peripheral nervous system disease, experimental autoimmune neuritis (EAN). We investigated the effect of POX on EAN in rats immunized with peripheral nerve myelin containing neuritogenic peptide SP26. At 200 mg/kg/day, there was significant suppression of clinical EAN, weight loss, and T cell proliferation to SP26 compared to controls. Proliferation of T cells from immunized rats to SP26 was suppressed by POX in vitro. These studies demonstrate a beneficial role for POX in EAN, with potential applicability to human autoimmune demyelination.
磷酸二酯酶抑制剂己酮可可碱（POX）已被证明在体外和体内具有多种免疫调节作用。它可抑制T细胞增殖、辅助性T1型细胞因子以及肿瘤坏死因子。我们推测POX可能对T细胞介导的自身免疫性周围神经系统疾病——实验性自身免疫性神经炎（EAN）具有体内免疫调节作用。我们研究了POX对用含神经生成肽SP26的周围神经髓鞘免疫的大鼠EAN的影响。与对照组相比，在200毫克/千克/天的剂量下，临床EAN、体重减轻以及T细胞对SP26的增殖均受到显著抑制。体外实验中，POX抑制了免疫大鼠的T细胞对SP26的增殖。这些研究证明了POX在EAN中具有有益作用，可能适用于人类自身免疫性脱髓鞘疾病。
