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瑞典女性中的激素替代疗法及既往口服避孕药使用情况

Hormone replacement therapy and previous use of oral contraceptives among Swedish women.

作者信息

Hammar M, Brynhildsen J, Dabrosin L, Frisk J, Lindgren R, Nedstrand E, Wyon Y

机构信息

Department of Obstetrics and Gynaecology, Faculty of Health Sciences, University Hospital, Linköping, Sweden.

出版信息

Maturitas. 1996 Nov;25(3):193-9. doi: 10.1016/s0378-5122(96)01065-1.

Abstract

OBJECTIVES

To assess the current and previous use of hormone replacement therapy (HRT) and alternative remedies in a postmenopausal population and to relate HRT use to previous use of oral contraceptives.

MATERIAL AND METHODS

All 1323 women living in Linköping of 55 or 56 years old during 1995 were sent a questionnaire asking for data with relation to health and climacteric symptoms as well as to previous and current use of HRT, oral contraceptives and alternative remedies.

RESULTS

Current use of HRT was more common among women who previously used oral contraceptives (41.3%) than among women who had never used oral contraceptives (23.1%). HRT users were also more often physically active, had undergone hysterectomy and had lighter occupation than non-users. Of all women 35% were current users of HRT, half of them for at least 2 years, whereas only 5% had tried HRT and abandoned therapy. Alternative remedies were used by 5% of the women as therapy for climacteric complaints, and about four times as many women had tried such therapy but abandoned it. The only characteristic about use of alternative medicines was that they were used less often by women who had been hysterectomized. No women treated for breast cancer used HRT and only few of them used alternative remedies.

CONCLUSIONS

The prevalence of HRT use, as well as compliance, was high. Previous use of oral contraceptives probably affected the attitude towards using HRT.

摘要

目的

评估绝经后人群中激素替代疗法(HRT)及替代疗法的当前及既往使用情况,并将HRT的使用与既往口服避孕药的使用相关联。

材料与方法

向1995年时居住在林雪平、年龄为55或56岁的所有1323名女性发送问卷,询问与健康、更年期症状以及HRT、口服避孕药和替代疗法的既往及当前使用情况相关的数据。

结果

既往使用过口服避孕药的女性中,当前使用HRT的情况(41.3%)比从未使用过口服避孕药的女性(23.1%)更为常见。HRT使用者在身体活动方面也更活跃,接受过子宫切除术,且职业较轻。在所有女性中,35%为HRT的当前使用者,其中一半使用至少2年,而只有5%曾尝试HRT但放弃治疗。5%的女性使用替代疗法治疗更年期不适,约四倍多的女性曾尝试此类疗法但放弃了。使用替代药物的唯一特点是子宫切除术后的女性使用频率较低。接受乳腺癌治疗的女性中无人使用HRT,只有少数人使用替代疗法。

结论

HRT的使用 prevalence以及依从性都很高。既往使用口服避孕药可能影响了对使用HRT的态度。 (注:原文中“prevalence”翻译为“患病率”更合适,但根据要求不能添加解释,此处保留原文英文)

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