Stadberg E, Mattsson L A, Milsom I
Department of Obstetrics and Gynecology, East Hospital, University of Göteborg, Sweden.
Acta Obstet Gynecol Scand. 1997 May;76(5):442-8. doi: 10.3109/00016349709047826.
To determine (i) the prevalence and severity of climacteric symptoms, and (ii) the prevalence of treatment for climacteric complaints, in a population based, random sample of Swedish women aged 46-62 years.
A random sample of 5990 women from the birth cohorts 1946, 1942, 1938, 1934 and 1930, resident in the city of Göteborg, was obtained from the population register. The women were invited by letter to complete a questionnaire concerning general health, reproductive history, climacteric symptoms (severity graded on a scale 0,1,2,3) and the treatment of climacteric complaints. The overall response rate was 76%.
The prevalence of climacteric symptoms was as follows: vasomotor symptoms 53%, depression/irritability 57%, sleeping disturbance 52%, muscle/joint pain 57%, loss of libido 37% and vaginal dryness 21%. Hormone replacement therapy (HRT) with medium potency estrogens was currently being used by 13.4% and 7.7% were using low potency estrogens. Medium potency estrogens had previously been used by 14% and 6% had used low potency estrogens. HRT was reported to be effective against the most common climacteric complaints in 70%-90%. Non-hormonal treatment regimens had been used by 45% of the women and 31-63% reported a positive effect on climacteric symptoms.
Although the majority of peri- and postmenopausal women reported suffering from climacteric complaints only 21% were current users of estrogens. Non-hormonal treatment modalities had been used by 45% of the women and were reported to have a good effect on climacteric symptoms in 45% compared to up to 90% of the HRT users.
在瑞典46 - 62岁女性的基于人群的随机样本中,确定(i)更年期症状的患病率和严重程度,以及(ii)更年期主诉的治疗患病率。
从哥德堡市的人口登记册中获取了出生队列1946、1942、1938、1934和1930年的5990名女性的随机样本。通过信件邀请这些女性填写一份关于一般健康、生殖史、更年期症状(严重程度按0、1、2、3级评分)和更年期主诉治疗的问卷。总体回复率为76%。
更年期症状的患病率如下:血管舒缩症状53%,抑郁/易怒57%,睡眠障碍52%,肌肉/关节疼痛57%,性欲减退37%,阴道干燥21%。目前13.4%的女性正在使用中效雌激素进行激素替代疗法(HRT),7.7%的女性正在使用低效雌激素。以前有14%的女性使用过中效雌激素,6%的女性使用过低效雌激素。据报告,HRT对70% - 90%的最常见更年期主诉有效。45%的女性使用过非激素治疗方案,31 - 63%的女性报告对更年期症状有积极影响。
尽管大多数围绝经期和绝经后女性报告有更年期主诉,但只有21%的女性目前在使用雌激素。45%的女性使用过非激素治疗方式,据报告,与高达90%的HRT使用者相比,45%的非激素治疗使用者对更年期症状有良好效果。