Gazelius B, Cui J G, Svensson M, Meyerson B, Linderoth B
Karolinska Institute Center for Pain Research, Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden.
Neuroreport. 1996 Nov 4;7(15-17):2619-23. doi: 10.1097/00001756-199611040-00042.
The incidence of behavioural signs of mononeuropathy in rats subjected to chronic constriction injury (CCI) of the sciatic nerve is unpredictable and often low. In the present study, an ischaemic lesion of the rat sciatic nerve was induced photochemically using a low power laser. In these rats tactile allodynia developed with a considerably greater incidence (95%) than in control rats subjected to CCI (45%). The allodynia lasted longer and was more prominent. Responses to thermal stimulation did not markedly differ between the two groups. The ischaemic lesions displayed marked degeneration, particularly of large myelinated fibres. The results suggest that laser irradiation of a peripheral nerve inducing a local photochemical reaction followed by Wallerian degeneration may be a convenient and reproducible experimental method of producing signs of peripheral mononeuropathy.
在遭受坐骨神经慢性压迫损伤（CCI）的大鼠中，单神经病行为体征的发生率不可预测且通常较低。在本研究中，使用低功率激光以光化学方式诱导大鼠坐骨神经缺血性损伤。在这些大鼠中，触觉异常性疼痛的发生率（95%）比遭受CCI的对照大鼠（45%）高得多。异常性疼痛持续时间更长且更明显。两组之间对热刺激的反应没有明显差异。缺血性损伤表现出明显的退变，尤其是大的有髓纤维。结果表明，激光照射外周神经诱导局部光化学反应继而发生沃勒变性，可能是产生外周单神经病体征的一种方便且可重复的实验方法。
