Balfour D J, Fagerström K O
Department of Pharmacology, University of Dundee Medical School, Ninewells Hospital, Scotland, UK.
Pharmacol Ther. 1996;72(1):51-81. doi: 10.1016/s0163-7258(96)00099-x.
During the last decade, nicotine has been used increasingly as an aid to smoking cessation and has been found to be a safe and efficacious treatment for the symptoms of nicotine withdrawal. This period has also seen significant advances in our understanding of the mechanisms underlying the psychopharmacological responses to nicotine, including, particularly, those that have been implicated in nicotine addiction. This paper reviews this decade of progress in the specific context of the therapeutic application of nicotine to the treatment of smoking cessation. Other putative future applications, particularly in the treatment of neurodegenerative disorders, are also reviewed.
在过去十年中，尼古丁越来越多地被用作戒烟辅助手段，并且已被发现是一种安全有效的治疗尼古丁戒断症状的方法。在此期间，我们对尼古丁心理药理学反应背后机制的理解也取得了重大进展，特别是那些与尼古丁成瘾有关的机制。本文在尼古丁治疗戒烟的具体治疗应用背景下回顾了这十年的进展。还对其他可能的未来应用进行了综述，特别是在神经退行性疾病治疗方面。
