Apoptosis in human retinal degenerations.
作者信息
Xu G Z, Li W W, Tso M O
机构信息
Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong.
出版信息
Trans Am Ophthalmol Soc. 1996;94:411-30; discussion 430-1.
Abstract
PURPOSE
This paper examined the role of apoptosis in human retinal degenerations including pathologic myopia, age-related macular degeneration, serous retinal detachment, retinal lattice, and paving stone degenerations.
METHOD
Thirty-seven enucleated human eyes with 1 of the above-mentioned retinal degenerations were studied by histopathology and by TdT-mediated biotin-dUTP nicked-end labelling (TUNEL) technique.
RESULTS
Tunnel labelling characteristic DNA fragmentation of apoptosis was observed in photoreceptor cells in 2 of the 4 eyes with pathologic myopia and in 4 of 16 eyes with age-related macular degeneration, 2 of which were exudative and 2 of which were atrophic. However, only a few scattered photoreceptor cells were labelled in 4 of 8 eyes with serous retinal detachment secondary to malignant melanoma of the choroid. Moreover, none of the photoreceptors cells in the 4 eyes with retinal lattice degeneration and 6 eyes with retinal paving stone degeneration were labelled.
CONCLUSIONS
Apoptosis is 1 of the important pathways of photoreceptor cell degeneration in pathologic myopia and age-related macular degeneration.
摘要
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本文引用的文献
1
Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice.
Neuron. 1993 Oct;11(4):595-605. doi: 10.1016/0896-6273(93)90072-y.
2
Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa.
Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):974-8. doi: 10.1073/pnas.91.3.974.
3
Apoptosis leads to photoreceptor degeneration in inherited retinal dystrophy of RCS rats.
Invest Ophthalmol Vis Sci. 1994 May;35(6):2693-9.
4
Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis.
Cancer Res. 1994 May 15;54(10):2591-7.
5
Basic fibroblast growth factor protects endothelial cells against radiation-induced programmed cell death in vitro and in vivo.
Cancer Res. 1994 May 15;54(10):2582-90.
6
[Quantification of basic fibroblast growth factor (bFGF) and transforming growth factor (TGF alpha) in rabbit aqueous humor after intraocular lens implantation].
Nippon Ganka Gakkai Zasshi. 1994 Apr;98(4):334-9.
7
Cell death and disposal in retinoblastoma: an electron microscopic study.
Graefes Arch Clin Exp Ophthalmol. 1994 Nov;232(11):635-45. doi: 10.1007/BF00171377.
8
Retinal photoreceptor dystrophies LI. Edward Jackson Memorial Lecture.
Am J Ophthalmol. 1995 May;119(5):543-62. doi: 10.1016/s0002-9394(14)70212-0.
9
Apoptotic photoreceptor degeneration in experimental retinal detachment.
Invest Ophthalmol Vis Sci. 1995 May;36(6):990-6.
10
Apoptotic photoreceptor cell death after traumatic retinal detachment in humans.
Arch Ophthalmol. 1995 Jul;113(7):880-6. doi: 10.1001/archopht.1995.01100070054025.
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