Appelman Z, Rabinerson D, Kaplan B, Caspi B
Dept. of Obstetrics and Gynecology, Kaplan Hospital, Rehovot.
Harefuah. 1996 Nov 1;131(9):297-9, 374.
Prenatal genetic diagnosis is recommended in multiple pregnancies because of the increased prevalence of genetic abnormalities in such fetuses. It can be done early by chorionic villus sampling or later by amniocentesis. Several studies have demonstrated the efficacy and safety of chorionic villus sampling in multiple pregnancies. Our study describes the results of this method in a twin pregnancy and in 3 triplet pregnancies, which represent 3% of the chorionic villus samplings performed in our ultrasound unit during 1989-95. All genetically deformed fetuses in these pregnancies were identified by chorionic villus sampling and the method was not associated with fetal loss. Our results confirm the safety and efficacy of chorionic villus sampling as expressed in the world literature.
由于多胎妊娠胎儿出现基因异常的几率增加，因此建议进行产前基因诊断。可以在孕早期通过绒毛取样进行，也可以在孕晚期通过羊膜穿刺术进行。多项研究已证实绒毛取样在多胎妊娠中的有效性和安全性。我们的研究描述了该方法应用于一例双胎妊娠和三例三胎妊娠的结果，这些病例占1989年至1995年间在我们超声科进行的绒毛取样的3%。这些妊娠中所有基因畸形胎儿均通过绒毛取样得以识别，且该方法未导致胎儿丢失。我们的结果证实了世界文献中所表明的绒毛取样的安全性和有效性。
