长期适度饮酒对心脏脑钠肽的影响。

Effect of chronic moderate ethanol consumption on heart brain natriuretic peptide.

作者信息

Guillaume P, Jankowski M, Gutkowska J, Gianoulakis C

机构信息

Douglas Hospital Research Centre, McGill University, Québec, Canada.

出版信息

Eur J Pharmacol. 1996 Nov 28;316(1):49-58. doi: 10.1016/s0014-2999(96)00644-9.

DOI:10.1016/s0014-2999(96)00644-9

PMID:8982650

Abstract

There is experimental evidence indicating that chronic moderate ethanol consumption delays the age-dependent increase in blood pressure. Since the brain natriuretic peptide (BNP) is a potent hypotensive hormone, the effect of chronic ethanol treatment on the heart BNP system was investigated, using spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. Chronic moderate ethanol consumption resulted in significantly lower circulating BNP levels for both SHR (206.9 +/- 18.5 vs. 306.9 +/- 28.1 pg/ml, n = 12, P < or = 0.05) and WKY rats (131.3 +/- 20.7 vs. 220.6 +/- 25.0 pg/ml, n = 12, P < or = 0.05). Left and right atrial BNP content and concentration in WKY rats and left atrial BNP content and concentration in SHR rats were augmented by the ethanol treatment, but not atrial BNP mRNA. In ventricular tissue, alcohol had no effect on total BNP content of either SHR or WKY rats, but it induced a significant elevation in ventricular BNP concentration (microgram/mg protein) and BNP mRNA in SHR, but not WKY rats. Thus, chronic ethanol treatment resulted in specific alterations in the activity of the heart BNP system.

摘要

有实验证据表明，长期适量饮酒可延缓随年龄增长出现的血压升高。由于脑钠肽（BNP）是一种强效降压激素，因此利用自发性高血压大鼠（SHR）和Wistar-Kyoto大鼠（WKY）研究了长期乙醇处理对心脏BNP系统的影响。长期适量饮酒导致SHR大鼠（206.9±18.5对306.9±28.1 pg/ml，n = 12，P≤0.05）和WKY大鼠（131.3±20.7对220.6±25.0 pg/ml，n = 12，P≤0.05）的循环BNP水平显著降低。乙醇处理使WKY大鼠左、右心房BNP含量和浓度以及SHR大鼠左心房BNP含量和浓度增加，但对心房BNP mRNA无影响。在心室组织中，乙醇对SHR大鼠和WKY大鼠的总BNP含量均无影响，但可使SHR大鼠心室BNP浓度（微克/毫克蛋白）和BNP mRNA显著升高，而对WKY大鼠无此作用。因此，长期乙醇处理导致心脏BNP系统活性发生特定改变。