[利用葱种子作为研究环境中诱变因素（药物）的初步试验]
[Use of Allium fistulosum L. seeds as a preliminary test for studying mutagenic factors in the environment (drugs)].
作者信息
Zolotareva G N, Ishkhakova E N, Oblapenko N G
出版信息
Tsitol Genet. 1977 Jan-Feb;11(1):62-5.
PMID:898274
Abstract
The mutagenic activity was studied for the following 14 psychotropic drugs: aminazinum, fluphenazinum-decanoate, thioproperazinum, reserpinum, chlordiazepoxidum, diazepam, oxazepam, trioxazin, tavor, dipheninum, hexamidinum, benzonalum, carbamazepinum, ethosuximidium. It is shown that carbamazepinum, benzonalum, chlordiazepoxidum considerably increase the frequency of chromosome aberrations in the Allium fistulosum L. cells. These drugs were selected for studying their mutagenic activity on the laboratory animals.
摘要
对以下14种精神药物的致突变活性进行了研究：氯丙嗪、氟奋乃静癸酸酯、硫丙嗪、利血平、氯氮卓、地西泮、奥沙西泮、三氧嗪、塔沃、地芬宁、己脒定、苯佐那酯、卡马西平、乙琥胺。结果表明，卡马西平、苯佐那酯、氯氮卓可显著增加葱属植物细胞中染色体畸变的频率。选择这些药物来研究它们对实验动物的致突变活性。
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