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[大鼠肝细胞暴露于亚硝酸二环己胺和环己胺油溶性盐后的电子显微镜研究]

[Electron microscopic study of rat hepatocytes following exposure to dicyclohexylamine nitrite and an oil-soluble salt of cyclohexylamine].

作者信息

Gordienko V M, Didenko M N

出版信息

Tsitol Genet. 1977 Jan-Feb;11(1):76-8.

PMID:898276
Abstract

Ultrastructural changes were studied in the rat liver under the effect of dicyclohexylamine nitrite and oil-soluble salt of cyclohexylamine in doses of 1/10 LD50. Both substances are stated to cause damages in the structure of hepatocytes even after three days of exposure. Dicyclohexylamine nitrite shows a more pronounced effect displayed in developed dystrophic changes of cytoplasmic organelles and in the presence of osmiophil bodies.

摘要

研究了亚硝酸二环己胺和环己胺油溶性盐以1/10 LD50剂量作用下大鼠肝脏的超微结构变化。据称,即使在暴露三天后,这两种物质都会对肝细胞结构造成损害。亚硝酸二环己胺的作用更为明显,表现为细胞质细胞器出现明显的营养不良性变化以及存在嗜锇小体。

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