Bariliak I R, Paustovskaia V V, Torbin V F
Arkh Anat Gistol Embriol. 1978;74(3):80-7.
The influence of some polymethylene amines (inhibitors protecting metals from atmospheric corrosion) on the generative function in general and on the embryogenesis in particular was studied. Such inhibitors as MCDA-II (dicyclohexylamine salt dissolving in oil), HDA (dicyclohexylamine nitrate) and M-I (cyclohexylamine salt dissolving in oil) were investigated by intraorganic injection during the whole course of gestation (21 days), 2 and 4 months. The compounds in question were stated to possess a pronounced gonado- and embryotoxic effect depending on the dose and chemical composition of the substance. The least active was M-I inhibitor. Doses not affecting rat gonades were: for HDA--0.825 mg/kg, MCDA-II--4.7 mg/kg, M-I--34.9 mg/kg; their embryonic effects were 0.54, 2.35 and 349 mg/kg respectively.
研究了某些聚亚甲基胺（保护金属免受大气腐蚀的抑制剂）对一般生殖功能，特别是胚胎发育的影响。通过在整个妊娠期（21天）、2个月和4个月内进行体内注射，研究了MCDA-II（溶于油的二环己胺盐）、HDA（二环己胺硝酸盐）和M-I（溶于油的环己胺盐）等抑制剂。据称，这些化合物根据物质的剂量和化学成分具有明显的性腺毒性和胚胎毒性作用。活性最低的是M-I抑制剂。不影响大鼠性腺的剂量分别为：HDA为0.825毫克/千克，MCDA-II为4.7毫克/千克，M-I为34.9毫克/千克；它们的胚胎效应分别为0.54、2.35和349毫克/千克。
