Lejeune F J, Mathieu M, Kenis Y
Tumori. 1977 May-Jun;63(3):289-98. doi: 10.1177/030089167706300307.
Ten hyperthermic isolation-perfusions with melphalan were performed for invasive malignant malenoma of the limbs. Four cases at stage II and with in transit metastases (up to 15 cm in diameter) had a complete regression. However, no improvement of survival was noticed: 4 out of 5 stage II patients who died, within 1 year after perfusion, developed a generalized disease. Systemic chemotherapy was administered in 3 patients after perfusion, but they died from distant metastases. The need for an adequate adjuvant treatment added to isolation perfusion is discussed.
对四肢侵袭性恶性黑色素瘤进行了10次美法仑热灌注隔离治疗。4例II期伴有远处转移（直径达15厘米）的患者完全缓解。然而，未观察到生存期改善：5例II期患者中有4例在灌注后1年内死亡，发生了全身播散性疾病。3例患者在灌注后接受了全身化疗，但死于远处转移。讨论了在隔离灌注基础上增加适当辅助治疗的必要性。
