Juliano R L
Department of Pharmacology, University of North Carolina at Chapel Hill, School of Medicine 27599, USA.
Princess Takamatsu Symp. 1994;24:118-24.
Integrins can trigger signals by activation of cytoplasmic tyrosine kinases, including pp125FAK. Preliminary evidence suggests that serine/threonine kinases such as ERKs may also be activated via integrins. Thus, there seems to be at least partial overlap between RTK signaling pathways and integrin signaling. In tumor cells, ectopic expression or over-expression of certain integrins such as alpha 5/beta 1 can result in reduced tumorigenesis. Presumably the effects of integrins on tumor growth are mediated by the integrin signaling pathway(s) involving FAK and ERKs. However, the precise mechanisms involved have not yet been elucidated.
整合素可通过激活包括pp125FAK在内的细胞质酪氨酸激酶来触发信号。初步证据表明，丝氨酸/苏氨酸激酶如细胞外调节蛋白激酶（ERKs）也可能通过整合素被激活。因此，受体酪氨酸激酶（RTK）信号通路和整合素信号通路之间似乎至少存在部分重叠。在肿瘤细胞中，某些整合素如α5/β1的异位表达或过表达可导致肿瘤发生减少。据推测，整合素对肿瘤生长的影响是由涉及黏着斑激酶（FAK）和细胞外调节蛋白激酶（ERKs）的整合素信号通路介导的。然而，其中涉及的精确机制尚未阐明。
