Juliano R
Dept of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill 27599, USA.
Bioessays. 1996 Nov;18(11):911-7. doi: 10.1002/bies.950181110.
Recently it has become clear that integrins and other adhesive receptors play an important role in the control of cell growth and differentiation. In various cell types, anchorage to the extracellular matrix via integrins strongly influences the ability of the cell to respond to soluble mitogens or to differentiation factors. Thus adhesive receptors must generate signals that influence cell behavior. Some of the pathways of adhesion receptor signaling are now beginning to be worked out, but there is still much to learn. In particular, the mechanistic basis for the cooperation between anchorage signals and signals from soluble growth and differentiation factors remains ill-defined. This review will examine some of the current information linking adhesion receptors to control of mitogenesis and differentiation.
最近已经明确，整合素和其他黏附受体在细胞生长和分化的控制中发挥着重要作用。在各种细胞类型中，通过整合素与细胞外基质的锚定强烈影响细胞对可溶性促有丝分裂原或分化因子作出反应的能力。因此，黏附受体必须产生影响细胞行为的信号。现在，一些黏附受体信号传导途径已开始得到阐明，但仍有许多有待了解。特别是，锚定信号与可溶性生长和分化因子信号之间协同作用的机制基础仍不明确。本综述将探讨一些将黏附受体与有丝分裂发生和分化控制联系起来的当前信息。
