Suppr超能文献

[嗜酸性粒细胞性食管炎:一种诊断不足的疾病?]

[Eosinophilic esophagitis: an underdiagnosed entity?].

作者信息

Borda F, Jiménez F J, Martínez Peñuela J M, Echarri A, Martín Granizo I, Aznarez R

机构信息

Servicio de Digestivo, Hospital de Navarra, Pamplona.

出版信息

Rev Esp Enferm Dig. 1996 Oct;88(10):701-4.

PMID:8983310
Abstract

Eosinophilic esophagitis is an exceptional entity, although the number of published cases has increased three times during the last 3 years. We report the case of an 18-year-old male with a long esophageal stenosis due to eosinophilic esophagitis. Clinical, radiologic, endoscopic and manometric outcome was satisfactory after prednisone therapy. Although isolated esophageal involvement may occur, disseminated eosinophilic esophago-gastro-intestinal disease is more frequent. The disease is usually diagnosed in young male patients, presenting with dysphagia and, to a lesser extent, chest pain. Previous allergic conditions are reported in 80% of cases and peripheral eosinophilia is present in 80% of patients. Esophageal stenosis is present in 72% of cases and manometric alterations are found in 47% of patients. Radiographic findings are nonspecific and include stenosis and rigidity. Endoscopic features are not specific either, but diagnosis may be achieved by endoscopic biopsy. Corticosteroids and sodium chromoglycate have proved to be useful, with good therapeutic response being reported in 90% of patients with this underestimated disease.

摘要

嗜酸性粒细胞性食管炎是一种罕见病,尽管在过去3年中已发表的病例数增加了两倍。我们报告了一例18岁男性因嗜酸性粒细胞性食管炎导致长段食管狭窄的病例。泼尼松治疗后临床、放射学、内镜及测压结果均令人满意。虽然可能发生孤立的食管受累,但播散性嗜酸性粒细胞性食管胃肠病更为常见。该病通常在年轻男性患者中诊断,表现为吞咽困难,程度较轻者有胸痛。80%的病例报告有既往过敏情况,80%的患者有外周血嗜酸性粒细胞增多。72%的病例存在食管狭窄,47%的患者有测压改变。影像学表现无特异性,包括狭窄和僵硬。内镜特征也不具有特异性,但可通过内镜活检实现诊断。皮质类固醇和色甘酸钠已被证明是有效的,据报道90%的患有这种被低估疾病的患者有良好的治疗反应。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验