Vertun-Baranowska B, Fijałkowska A, Tomkowski W, Filipecki S, Szymańska D
Kliniki Chorób Wewnetrznych.
Pneumonol Alergol Pol. 1996;64(7-8):392-402.
The incidence and clinical significance of pulmonary embolism (PE) in pulmonary malignancy were analysed among 111 autopsy cases including: 65 primary and 24 metastatic lung cancer, 8 hematological malignancies and 14-malignant pleural mesothelioma. In 34 (31%) cases PE was found, in 4 (12%) patients cancer tissue emboli was documented. In nonsmall cell lung cancer the frequency of PE was 40%, compared to 24% in small cell, 25% in metastatic lung cancer and 14% in mesothelioma. Deep venous thrombosis of lower extremities was the source of thrombotic material in 35% cases. In remaining cases the sources of thrombotic material were different (caval vein inferior, superior, and their main branches, right heart cavities, pulmonary artery). In 8 patients with PE the acute form of DIC was observed. In 15 (44%) patients the clinical ante mortem diagnosis of PE was done. In 26% of all analysed cases PE was the direct cause of death. We concluded that PE is a frequent and dangerous complication of lung neoplasms. Clinical diagnosis can be extremely difficult.
对111例尸检病例分析了肺恶性肿瘤中肺栓塞（PE）的发生率及临床意义，其中包括65例原发性肺癌、24例转移性肺癌、8例血液系统恶性肿瘤和14例恶性胸膜间皮瘤。在34例（31%）病例中发现有PE，4例（12%）患者记录有癌组织栓子。在非小细胞肺癌中PE的发生率为40%，小细胞肺癌为24%，转移性肺癌为25%，间皮瘤为14%。35%的病例中下肢深静脉血栓是血栓物质的来源。其余病例中血栓物质的来源各不相同（下腔静脉、上腔静脉及其主要分支、右心腔、肺动脉）。8例PE患者观察到急性弥散性血管内凝血（DIC）。15例（44%）患者生前临床诊断为PE。在所有分析病例中，26%的患者PE是直接死亡原因。我们得出结论，PE是肺部肿瘤常见且危险的并发症。临床诊断可能极其困难。
