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腔内近距离放射治疗在远距离放射治疗后局部失败的非小细胞肺癌患者治疗中的应用

[Use of intraluminal brachytherapy for treatment of patients with non-small cell lung cancer in cases of local failure after teleradiotherapy].

作者信息

Makarewicz R, Kuźmińska A

机构信息

Oddział Brachyterapii Regionalnego Centrum Onkologii w Bydgosczy.

出版信息

Pneumonol Alergol Pol. 1996;64(7-8):444-9.

PMID:8983445
Abstract

Remote afterloading high-dose-rate brachytherapy was used for the treatment in 38 patients with non-small cell lung cancer local failure after previous teleradiotherapy. The high dose unit we used is called microSelectron HDR. A dose of 18 Gy or 22.5 Gy was delivered in three fractions repeated weekly. Before treatment, symptomatic occlusions were seen in all patients. After treatment palliative improvement was seen in 30 patients (78.9%). The average follow up time was 7.2 months and range from 3 to 17. Median response time was 6.8 months. 12 patients died meanwhile. The procedure has been well tolerated with low toxicity. We conclude that palliative endobronchial high dose rate brachytherapy is a useful palliative modality in patients with recurrent endobronchial symptomatic carcinoma.

摘要

对38例先前接受远距离放疗后出现局部失败的非小细胞肺癌患者采用远程后装高剂量率近距离放射治疗。我们使用的高剂量装置称为microSelectron HDR。每周重复三次,每次给予18 Gy或22.5 Gy的剂量。治疗前,所有患者均出现症状性阻塞。治疗后,30例患者(78.9%)出现姑息性改善。平均随访时间为7.2个月,范围为3至17个月。中位反应时间为6.8个月。同时有12例患者死亡。该治疗方法耐受性良好,毒性较低。我们得出结论,姑息性支气管内高剂量率近距离放射治疗是复发性支气管内有症状癌患者有用的姑息治疗方式。

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