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[神经生长因子对大鼠坐骨神经纤维再生的影响]

[The effect of nerve growth factor on regeneration of the fibers in the rat sciatic nerve].

作者信息

Zhuk O N, Kaliunov V N

出版信息

Morfologiia. 1996;110(4):113-5.

PMID:8983497
Abstract

Exogenic nerve growth factor in the crushed nerve of rat promotes the development of reparative-regenerative processes. This was established by electron microscopy and electrophysiological method and is expressed through the activation of phagocytosis in the remained crushed axons in distal segments, relatively more early and vast penetration of the growing fibres to the outside of the traumatic zone, a single supramaximum stimulation of proximal region above the appearance and growth of action potential amplitude and also its spreading to the periphery as compared to control animals, treated with equal amounts of isotonic natrium chloride.

摘要

大鼠坐骨神经挤压伤局部外源性神经生长因子可促进修复再生过程的发展。这是通过电子显微镜和电生理方法得以证实的,具体表现为:损伤远端剩余挤压轴突的吞噬作用较早且更为广泛地被激活;生长纤维较早且大量地向创伤区域外生长;在动作电位出现和幅度增大之前,对近端区域进行单次超强刺激,动作电位不仅出现且其幅度增大,并向周围扩散,而给予等量等渗氯化钠处理的对照动物则无此现象。

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1
[The effect of nerve growth factor on regeneration of the fibers in the rat sciatic nerve].[神经生长因子对大鼠坐骨神经纤维再生的影响]
Morfologiia. 1996;110(4):113-5.
2
Effect of nerve growth factor on the regeneration of fibers in the rat sciatic nerve.神经生长因子对大鼠坐骨神经纤维再生的影响。
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Studies on the degenerative and regenerative phenomena occurring after transection and repair of the sciatic nerve in rats: effects of acetyl-L-carnitine.大鼠坐骨神经横断及修复后发生的退行性和再生现象的研究:乙酰-L-肉碱的作用
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Zhongguo Yao Li Xue Bao. 1997 Nov;18(6):501-4.