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[医疗保健中的新生儿惊厥。I. 发病率、病因及临床方面]

[Neonatal convulsions in health care. I. Incidence, etiology and clinical aspects].

作者信息

Carrascosa M C, Mariínez-Gutiérrez A, Onsurbe I, Vázquez M S, Catalán B, Tébar R

机构信息

Servicio de Neuropediatria, Hospital General de Albacete, España.

出版信息

Rev Neurol. 1996 Oct;24(134):1258-62.

PMID:8983725
Abstract

OBJECTIVE

To determine the incidence, etiology and course of neonatal convulsions in the Albacete Health District between 1991 and 1993.

DESIGN

A descriptive study of retrospective cohorts.

SCOPE

12,427 new born babies in the province of Albacete. The Hospital General de Albacete looks after a population of 376,071 inhabitants, attends 82% of the births in this area and its Neonatology Department is the only one in the province.

METHOD

Incidence: we found 25 new born babies (RN) with neonatal convulsions: absolute incidence (IA) in live RN0/00.; IA in live full-term RN (RNI) 1.4(0/00); IA in preterm RN (RNPT) 13.4(0/00) and in immature RN (with a gestational age of < 29 weeks) 27.8(0/00).

ETIOLOGY

hypoxic-ischaemic encephalopathy 32%, malformations or cerebral dysgenesis 24%, intracranial hemorrhage 16%, with less frequency: infections, metabolic and pharmacological changes 8%, epileptogenic diagnosis 4%.

COURSE

10 of the RN (40%) died, 8 (32%) had sequelae, although in 3 cases these were transient, and 7 had developed normally (28%). Other relevant aspects are described: neurological findings between crises, type of crisis, EEG and neuroimaging techniques.

DISCUSSION

We attribute the poor prognosis of our series, as compared to other published series, to an increase in the incidence of convulsions associated with a worse prognosis (RN with antepartum fetal distress, cerebral malformations and metabolic encephalopathies), and a decrease in acute intercurrent conditions; hypoglucemia, hipocalcemia and hypothermia, which do not leave sequelae after treatment. Also when methods of clinical inclusion/EEG are used, evaluating only the epileptic phenomena, convulsive crises with minimal clinical signs are observed.

摘要

目的

确定1991年至1993年阿尔瓦塞特卫生区新生儿惊厥的发病率、病因及病程。

设计

回顾性队列描述性研究。

范围

阿尔瓦塞特省12427名新生儿。阿尔瓦塞特综合医院负责照料376071名居民,接收该地区82%的分娩病例,其新生儿科是该省唯一的新生儿科。

方法

发病率:我们发现25名患有新生儿惊厥的新生儿:活产新生儿的绝对发病率(IA)为0/1000;足月活产新生儿的发病率(RNI)为1.4/1000;早产新生儿的发病率(RNPT)为13.4/1000,未成熟新生儿(胎龄<29周)的发病率为27.8/1000。

病因

缺氧缺血性脑病32%,畸形或脑发育不全24%,颅内出血16%,较少见的有:感染、代谢及药物性改变8%,癫痫源性诊断4%。

病程

10名新生儿(40%)死亡,8名(32%)有后遗症,尽管3例为短暂性后遗症,7名发育正常(28%)。还描述了其他相关方面:发作间期的神经学表现、发作类型、脑电图及神经影像学检查。

讨论

与其他已发表的系列研究相比,我们的系列研究预后较差,原因是与预后较差相关的惊厥发病率增加(伴有产前胎儿窘迫、脑畸形及代谢性脑病的新生儿),以及急性并发疾病减少;低血糖、低钙血症及体温过低,这些疾病治疗后不留后遗症。此外,当采用临床纳入/脑电图方法时,仅评估癫痫现象,会观察到临床症状轻微的惊厥发作。

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