[The level of free histamine and free serotonin in the blood plasma in polycythemia vera].

Fluorimetric analysis was performed of blood plasma content of free histamine and free serotonin in 26 patients with polycythemia vera (PV) and 29 essentially healthy individuals. There has been established an elevation of blood plasma free histamine and free serotonin concentration in PV patients (p) as compared with those in healthy subjects. The ratio of free histamine: free serotonin in PV patients' blood plasma has gotten significantly decreased (p) as compared with the healthy individuals. The above findings might be regarded as reflecting metabolic disorders due to retardation of bloodflow and increase in viscosity of blood caused by augmentation of the mass of circulating erythrocytes in PV.