Celentano A, Mancini F P, Crivaro M, Palmieri V, Tammaro P, De Stefano V, Oliviero M, Di Palma Esposito N, Pietropaolo I, Tufano A, Di Minno G, de Divitiis O
Centro Inter Universitario per la Ricerca Cardiovascolare (GIMEC), Napoli.
Cardiologia. 1996 Oct;41(10):995-1000.
To assess the relationship between the angiotensin converting enzyme (ACE) gene I/D polymorphism, blood pressure (BP) and family history of hypertension, 133 hypertensive subjects (mean age 50 +/- 9 years, 78 males, 55 females) were selected according to both casual supine BP > 140/90 mmHg and ambulatory BP > 134/88 mmHg. Drug treatment was discontinued 2 weeks before entering the study. Subjects with myocardial ischemia, as well as those with "white coat" hypertension, were excluded. The study population was subclassified according to age < or = 50 years. Polymerase chain reaction was used to detect the I/D polymorphism of the ACE gene, and the DD genotype was analysed twice. The frequencies of the I and D allele were 42 and 58%, and the distribution of the ID+ II and DD genotypes were 69 and 31% respectively. No significant relation was found among ACE genotypes (DD vs ID+ II) and casual systolic or diastolic BP as well as ambulatory BP, both in the whole study population and in the subpopulation < 50 years old. No difference was found also in the distribution of dippers and no dippers, as well as in the distribution of subjects with a positive family history in the whole sample and hypertensives < 50 years old.
为评估血管紧张素转换酶（ACE）基因I/D多态性、血压（BP）与高血压家族史之间的关系，根据偶测仰卧位血压>140/90 mmHg和动态血压>134/88 mmHg，选取了133例高血压患者（平均年龄50±9岁，男性78例，女性55例）。在进入研究前2周停用药物治疗。排除心肌缺血患者以及“白大衣”高血压患者。研究人群根据年龄≤50岁进行亚组划分。采用聚合酶链反应检测ACE基因的I/D多态性，DD基因型检测两次。I和D等位基因频率分别为42%和58%，ID + II和DD基因型分布分别为69%和31%。在整个研究人群以及年龄<50岁的亚组人群中，未发现ACE基因型（DD与ID + II）与偶测收缩压或舒张压以及动态血压之间存在显著关系。在整个样本以及年龄<50岁的高血压患者中，勺型血压者与非勺型血压者的分布以及有阳性家族史者的分布也未发现差异。
