Knoring B E, Simbirtsev A S, Sakharova I I, Kotov A I
NII Phthisiopulmonology, Saint-Petersburg, Russian Federation.
Probl Tuberk. 1996(5):35-9.
The production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) by peripheral mononuclears induced by prodigiosane, tuberculin, phytohemagglutinin and unduced and the serum levels of the above cytokines were studied. There was an relationship between the production of TNF-alpha in the patients' peripheral blood and the type and pattern of a tuberculosis process. The similar tendencies were found in the production of IL-1 beta. It was found that the production of IL-1 beta was higher in patients with a more predominant humoral immune response and that of TNF-alpha was greater in those with a more cellular response. There were the most marked relationships of cytokine synthesis to the degree of clinical parameters in prodigiosan cell induction of cells and to immunological parameters in tuberculin-induced cell stimulation.
研究了灵菌红素、结核菌素、植物血凝素诱导外周单核细胞产生肿瘤坏死因子-α（TNF-α）和白细胞介素-1β（IL-1β）的情况以及未诱导时的情况，同时检测了上述细胞因子的血清水平。患者外周血中TNF-α的产生与结核病进程的类型和模式之间存在关联。在IL-1β的产生方面也发现了类似趋势。结果发现，体液免疫反应更占优势的患者中IL-1β的产生较高，而细胞反应更强的患者中TNF-α的产生更多。在灵菌红素诱导细胞时，细胞因子合成与临床参数程度之间以及在结核菌素诱导细胞刺激时与免疫参数之间存在最显著的关系。
