Knoring B E, Simbirtsev A S, Sakharova I Ia, Kotov A Iu, Pisareva N V, Resnianskaia T B
Probl Tuberk. 1998(3):67-71.
The relationship of the production of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha) and interleukin-2 (IL-2) to the pattern and etiology was studied in patients with pulmonary tuberculosis (n = 74) and nontuberculous lung diseases (n = 28). There was an inverse correlation between the production of the proinflammatory cytokines IL-1 beta and TNF-alpha and the main T-cellular immunity IL-2. An exacerbation of a tuberculous process is accompanied by an increase in IL-1 beta and TNF-alpha productions and by a decrease in inducted IL-2 synthesis. With favourable changes, there was, on the contrary, a reduction in the levels of IL-1 beta and TNF-alpha and a rise in IL-2. There were differences in the rate of cytokine synthesis in pulmonary tuberculosis, lung cancer, and pneumonia. Patients with cancer are most typified by the spontaneous mononuclear production of serum TNF-alpha and by the low level of IL-2 when PGA is stimulated. On the contrary, the least TNF-alpha synthesis and pronounced IL-2 production in pneumonia. A combination of the high production of PPD-induced IL-1 beta and PGA-stimulated IL-2 is more specific to patients with infiltrative pulmonary tuberculosis.
在74例肺结核患者和28例非结核性肺部疾病患者中，研究了白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）和白细胞介素-2（IL-2）的产生与疾病类型及病因之间的关系。促炎细胞因子IL-1β和TNF-α的产生与主要的T细胞免疫因子IL-2之间呈负相关。结核病情加重时，IL-1β和TNF-α的产生增加，诱导的IL-2合成减少。相反，病情好转时，IL-1β和TNF-α水平降低，IL-2升高。肺结核、肺癌和肺炎患者的细胞因子合成速率存在差异。癌症患者的典型特征是血清TNF-α的自发单核细胞产生以及在刺激植物血凝素（PGA）时IL-2水平较低。相反，肺炎患者的TNF-α合成最少，IL-2产生明显。PPD诱导的IL-1β高产生与PGA刺激的IL-2相结合，对浸润性肺结核患者更具特异性。
