Stárka L, Hill M, Lapcík O, Hampl R
Endokrinologický ústav, Praha.
Vnitr Lek. 1996 Sep;42(9):620-3.
The authors assessed in the plasma of 156 boys and men aged 6 - 65 years and in prostatic tissues of 15 men aged 55 - 82 years epitestosterone, C19-steroid with anti-androgenic properties. It was revealed that during the prepubertal period the epitestosterone level is higher than that of testosterone, in adult age the epitestosterone is about ten times lower than the testosterone concentration. In tissue of hyperplastic prostates the epitestosterone level is comparable with the androstendione level; it is about twice as high as the testosterone level and approximately half as high as the dihydrotestosterone level. Thus at least during the prepubertal period in boys and in the androgen-dependent prostate tissue a more significant participation of epitestosterone in the regulation of androgen-dependent processes must be taken into consideration.
作者评估了156名6至65岁男孩和男性的血浆以及15名55至82岁男性的前列腺组织中的表睾酮，这是一种具有抗雄激素特性的C19类固醇。结果显示，青春期前表睾酮水平高于睾酮水平，成年后表睾酮水平比睾酮浓度低约10倍。在增生性前列腺组织中，表睾酮水平与雄烯二酮水平相当；约为睾酮水平的两倍，约为双氢睾酮水平的一半。因此，至少在男孩青春期前以及雄激素依赖的前列腺组织中，必须考虑表睾酮在雄激素依赖过程调节中更重要的参与作用。
