Stárka L, Hampl R, Hill M, Lapcík O, Bílek R, Petrik R
Institute of Endocrinology, Praha, The Czech Republic.
Eur J Clin Chem Clin Biochem. 1997 Jun;35(6):469-73. doi: 10.1515/cclm.1997.35.6.469.
Epitestosterone, a C19-steroid with anti-androgenic activity, was determined in the plasma of 234 boys and men from the ages of 6-86 years, and in the prostate tissue of 15 men 55-82 years of age. It was documented that, while in adulthood the concentration of epitestosterone is about ten times lower than the concentration of testosterone, in the pre-pubertal period the level of epitestosterone is similar or even higher than that of testosterone. In the hyperplastic prostate tissue the content of epitestosterone is comparable to that of androstenedione, it is about twice as high as the content of testosterone and approximately half that of the content of dihydrotestosterone. At least in the case of pre-pubertal boys and in the prostatic tissue it is therefore possible to include epitestosterone into consideration as a regulatory factor for the androgen-dependent events.
表睾酮是一种具有抗雄激素活性的C19甾体，在234名6至86岁男孩和男性的血浆以及15名55至82岁男性的前列腺组织中进行了测定。据记录，在成年期，表睾酮的浓度比睾酮浓度低约10倍，而在青春期前，表睾酮水平与睾酮相似甚至更高。在增生性前列腺组织中，表睾酮的含量与雄烯二酮相当，约为睾酮含量的两倍，约为双氢睾酮含量的一半。因此，至少在青春期前男孩和前列腺组织的情况下，有可能将表睾酮视为雄激素依赖性事件的调节因子。
