米诺环素诱导的关节炎，伴有发热、网状青斑和抗中性粒细胞胞浆抗体。
Minocycline induced arthritis associated with fever, livedo reticularis, and pANCA.
作者信息
Elkayam O, Yaron M, Caspi D
机构信息
Department of Rheumatology, Ichilov Hospital, Tel Aviv, Israel.
出版信息
Ann Rheum Dis. 1996 Oct;55(10):769-71. doi: 10.1136/ard.55.10.769.
Abstract
OBJECTIVE
To describe a novel iatrogenic immunological reaction produced by minocycline.
CASE REPORTS
The clinical course and laboratory results of three women who presented with similar rheumatological manifestations after a prolonged exposure to minocycline are described. All three presented a unique reaction manifested by fever, arthritis/arthralgia and livedo reticularis during treatment with minocycline for acne vulgaris. The clinical syndrome was associated with high titre of serum perinuclear anticytoplasmatic antibodies (p-ANCA) and antimyeloperoxidase antibody (anti-MPO). Symptoms resolved after stopping the drug and recurred promptly after rechallenge in all three patients.
CONCLUSIONS
Minocycline, which is widely used in the treatment of acne, often without adequate supervision, may induce arthritis and livedo vasculitis associated with anti-MPO.
摘要
目的
描述一种由米诺环素引起的新型医源性免疫反应。
病例报告
描述了三名女性在长期使用米诺环素后出现类似风湿病表现的临床过程和实验室检查结果。这三名患者在使用米诺环素治疗寻常痤疮期间均出现了一种独特的反应，表现为发热、关节炎/关节痛和网状青斑。临床综合征与高滴度的血清核周抗细胞质抗体（p-ANCA）和抗髓过氧化物酶抗体（抗MPO）相关。所有三名患者停药后症状缓解，再次用药后症状迅速复发。
结论
米诺环素广泛用于治疗痤疮，且常常缺乏充分监管，可能诱发与抗MPO相关的关节炎和血管性青斑。
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