Dolman K M, Gans R O, Vervaat T J, Zevenbergen G, Maingay D, Nikkels R E, Donker A J, von dem Borne A E, Goldschmeding R
Central Laboratory, Netherlands Red Cross Blood Transfusion Service, Amsterdam.
Lancet. 1993 Sep 11;342(8872):651-2. doi: 10.1016/0140-6736(93)91761-a.
Vasculitis is a rare complication of propylthiouracil therapy. Antineutrophil cytoplasmic antibodies (ANCA) have been described in association with several vasculitic disorders. We report detection of ANCA against human neutrophil elastase, proteinase 3, and myeloperoxidase in serum from six patients who developed evidence of vasculitis during propylthiouracil treatment of hyperthyroidism. On withdrawal of the drug ANCA concentrations fell and clinical symptoms resolved completely.
血管炎是丙硫氧嘧啶治疗的一种罕见并发症。抗中性粒细胞胞浆抗体（ANCA）已被描述与多种血管炎疾病相关。我们报告了在6例甲状腺功能亢进症患者接受丙硫氧嘧啶治疗期间出现血管炎证据的患者血清中检测到抗人中性粒细胞弹性蛋白酶、蛋白酶3和髓过氧化物酶的ANCA。停药后，ANCA浓度下降，临床症状完全缓解。
