Maliugin A V, Shteĭnshneĭder A Ia, Kosykh V A, Alquier C, Lafont H, Misharin A Iu
Bioorg Khim. 1996 Aug;22(8):606-10.
Synthesis of 3 beta-(2-hydroxyethoxy)cholest-5-ene, 3 beta-(2-hydroxyethoxy)cholest-5-en-7-one, 3 beta-(2-hydroxyethoxy)-7 beta-hydroxycholest-5-ene, 3 beta-(2-hydroxyethoxy)-5 alpha, 6 alpha-epoxycholestane, and 3 beta-(2-hydroxyethoxy) -5 alpha, 6 beta-dihydroxycholestane was described. Substances obtained inhibited cholesterol biosynthesis in the rabbit hepatocyte cell culture with ID 50 from 5.5(+/-0.7) x 10(-8) to 1.3(+/-0.2) x 10(-5) M and also to a remarkable extent the cell protein biosynthesis.
描述了3β-(2-羟基乙氧基)胆甾-5-烯、3β-(2-羟基乙氧基)胆甾-5-烯-7-酮、3β-(2-羟基乙氧基)-7β-羟基胆甾-5-烯、3β-(2-羟基乙氧基)-5α,6α-环氧胆甾烷和3β-(2-羟基乙氧基)-5α,6β-二羟基胆甾烷的合成。所获得的物质在兔肝细胞培养物中抑制胆固醇生物合成，半数抑制浓度（ID 50）为5.5(±0.7)×10(-8)至1.3(±0.2)×10(-5) M，并且在很大程度上也抑制细胞蛋白质生物合成。
