Mansueto S, D'Ancona F P, Colletti P, Graceffa R, La Seta F, Pecoraro V, Gambino G, Grillo G, Vitale G, Richiusa P, D'Agostino P, Cillari E
Institute of Internal Medicine, Laboratory of Immunology, University of Palermo, Italy.
J Infect Dis. 1997 Jan;175(1):142-5. doi: 10.1093/infdis/175.1.142.
Sera and urine samples from 115 Sicilian patients with boutonneuse fever (BF), obtained at the time of diagnosis and after clinical recovery, were analyzed for concentrations of interleukin (IL)-2 and soluble IL-2 receptor (sIL-2R). There were significantly high levels of sIL-2R in the urine and sera of patients with acute BF compared with healthy controls, and the values returned to normal following successful chemotherapy. The data indicate that the sIL-2R urine concentrations correlated directly with the sIL-2R sera levels. In contrast, in all tested sera and urine samples, IL-2 levels were normal. Furthermore, a reduction in IL-2 production by peripheral blood mononuclear cells from acute BF patients was also observed. sIL-2R represents an unspecific marker useful to monitor the evolution of BF.
对115名西西里岛纽扣热（BF）患者在诊断时和临床康复后采集的血清和尿液样本进行分析，检测白细胞介素（IL）-2和可溶性IL-2受体（sIL-2R）的浓度。与健康对照相比，急性BF患者尿液和血清中的sIL-2R水平显著升高，成功化疗后这些值恢复正常。数据表明，sIL-2R尿液浓度与sIL-2R血清水平直接相关。相比之下，在所有检测的血清和尿液样本中，IL-2水平均正常。此外，还观察到急性BF患者外周血单核细胞产生IL-2减少。sIL-2R是一种用于监测BF病情发展的非特异性标志物。
