Mansueto S, Vitale G, Mocciaro C, Gambino G, Colletti P, Mansueto P, Spinelli A, Affronti M, Chifari N, Arcoleo F, Milano S, Cillari E
Institute of Internal Medicine, University of Palermo, Italy.
Clin Exp Immunol. 1998 Mar;111(3):555-8. doi: 10.1046/j.1365-2249.1998.00502.x.
The serum levels of beta2-microglobulin (beta2-M), soluble HLA class I antigen (sHLA-I), soluble CD4 (sCD4) and CD8 (sCD8) were studied in 98 Sicilian patients with Boutonneuse fever (BF). In different stages of infection all markers were significantly increased in sera from Sicilian patients with acute BF compared with healthy controls. sCD8 and sHLA-I reached the peak in the second week after the onset of symptoms, whereas sCD4 and beta2-M reached the peak in the first week. Afterwards sCD8 decreased to the levels of controls within the third week, the other parameters decreased later and were unmodified until the third week of infection. Significant correlations were found between sCD4 and sCD8 and the sIL-2R, as well as between serum levels of beta2-M and sCD8. The reduction of CD3+ and CD4+ and the increase of CD8+ T cells in the blood indicate that these cells are involved in the response to rickettsia, and their activation might be in part responsible for the release of sCD4 and sCD8. Our data suggest that these soluble markers, indexes of immune activation of T cells both in the circulation and the affected tissues, may be used in monitoring BF evolution.
对98例患有纽扣热（BF）的西西里岛患者的血清β2-微球蛋白（β2-M）、可溶性HLA I类抗原（sHLA-I）、可溶性CD4（sCD4）和CD8（sCD8）水平进行了研究。与健康对照相比，在急性BF的西西里岛患者血清中，所有标志物在感染的不同阶段均显著升高。sCD8和sHLA-I在症状出现后的第二周达到峰值，而sCD4和β2-M在第一周达到峰值。此后，sCD8在第三周内降至对照水平，其他参数随后下降，直到感染第三周才保持不变。发现sCD4和sCD8与sIL-2R之间以及β2-M和sCD8的血清水平之间存在显著相关性。血液中CD3+和CD4+的减少以及CD8+T细胞的增加表明这些细胞参与了对立克次体的反应，它们的激活可能部分导致了sCD4和sCD8的释放。我们的数据表明，这些可溶性标志物作为循环和受影响组织中T细胞免疫激活的指标，可用于监测BF的病程。
