Woo K, Joo M, Narayanan K, Kim K H, Makino S
Department of Microbiology, The University of Texas at Austin, 78712-1095, USA.
J Virol. 1997 Jan;71(1):824-7. doi: 10.1128/JVI.71.1.824-827.1997.
Studies of defective interfering (DI) RNAs of the murine coronavirus mouse hepatitis virus (MHV) suggest that a 69-nucleotide-long packaging signal is necessary for MHV genomic RNA packaging into MHV particles. In this study we showed that when RNA transcripts that consisted of a non-MHV sequence and the packaging signal were expressed in MHV-infected cells, they were packaged into MHV particles. Those RNA transcripts that lacked the packaging signal or those containing a mutated packaging signal did not package efficiently. Thus, the presence of the packaging signal was sufficient for RNA packaging into MHV particles.
对鼠冠状病毒小鼠肝炎病毒(MHV)的缺陷干扰(DI)RNA的研究表明,一个69个核苷酸长的包装信号对于将MHV基因组RNA包装到MHV颗粒中是必需的。在本研究中,我们发现,当由非MHV序列和包装信号组成的RNA转录本在MHV感染的细胞中表达时,它们会被包装到MHV颗粒中。那些缺乏包装信号的RNA转录本或包含突变包装信号的转录本不能有效地包装。因此,包装信号的存在足以使RNA包装到MHV颗粒中。