Frucht-Pery J, Solomon A, Siganos C S, Shvartzenberg T, Richard C, Trinquand C
Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel.
Cornea. 1997 Jan;16(1):42-7.
To evaluate the effect of topical indomethacin 0.1% on signs and symptoms in inflamed pterygium and pinguecula.
Fifty-one consecutive patients who had inflamed pterygium (n = 32) or pinguecula (n = 19) were studied in a randomized, double-masked, controlled way. Objective signs (conjunctival congestion, redness, edema, and staining of cornea) and subjective complaints (photophobia, pain, foreign-body sensation, discomfort, and tearing) were evaluated and scored. In addition, we evaluated total signs, total symptoms, and total score. Group 1 (n = 25) received topical indomethacin 0.1% solution and group 2 (n = 26) received a placebo six times daily for 3 days, then four times daily for 11 days. Patients were examined before and at days 3, 7, and 14 after the treatment began.
In group 1 at day 3, the scores of total signs, total symptoms, and total score decreased (p = 0.001), and they further decreased after 14 days (p = 0.02 to p = 0.05). In group 2 at day 3 these parameters also significantly decreased (p = 0.01 to p = 0.02), but no further improvement occurred after 14 days. Comparing groups 1 and 2 revealed a decrease in scores in group 1 for total signs, total symptoms, and total score at days 3, 7, and 14 (p = 0.03 to p = 0.002) except for total signs after 14 days (p = NS). All the patients reported mild stinging for < 1 min after administration of the drops.
This study indicates that topical indomethacin solution 0.1% is a useful treatment for inflamed pterygium and pinguecula.
评估0.1%吲哚美辛局部用药对翼状胬肉和睑裂斑炎体征及症状的影响。
对51例连续的患有翼状胬肉（n = 32）或睑裂斑炎（n = 19）的患者进行随机、双盲、对照研究。评估并记录客观体征（结膜充血、发红、水肿及角膜染色）和主观症状（畏光、疼痛、异物感、不适及流泪）。此外，还评估了体征总分、症状总分及总评分。第1组（n = 25）每日6次局部使用0.1%吲哚美辛溶液，第2组（n = 26）每日6次使用安慰剂，共3天，然后每日4次，共11天。在治疗开始前及治疗开始后的第3、7和14天对患者进行检查。
第1组在第3天时，体征总分、症状总分及总评分均下降（p = 0.001），14天后进一步下降（p = 0.02至p = 0.05）。第2组在第3天时这些参数也显著下降（p = 0.01至p = 0.02），但14天后未进一步改善。比较第1组和第2组发现，第1组在第3、7和14天时体征总分、症状总分及总评分均下降（p = 0.03至p = 0.002），14天后体征总分除外（p = 无显著性差异）。所有患者在滴眼药水后均报告有< 1分钟的轻度刺痛。
本研究表明，0.1%吲哚美辛局部溶液对翼状胬肉和睑裂斑炎是一种有效的治疗方法。
