Gill K S, Yannariello-Brown J, Patel J, Nakajima N, Rajaraman S, Trocmé S D
Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, School of Medicine, Galveston 77555-0787, USA.
Cornea. 1997 Jan;16(1):107-11.
Recent reports have demonstrated the expression of intercellular adhesion molecule-1 (ICAM-1; CD54) on the epithelium in various allergic diseases and inflammatory conditions, including the bronchial epithelium of patients with allergic asthma, conjunctival epithelium of allergic patients after allergen-specific challenge, and corneal epithelium of rejected corneal allografts. We investigated the presence of ICAM-1 expression on the corneal epithelium from a patient with vernal keratoconjunctivitis (VKC). Immunohistochemical staining of the diseased cornea demonstrated abundant ICAM-1 expression on the corneal epithelium. Immunoreactive ICAM-1 appeared to localize primarily to the cells of the basal and middle layers of the corneal epithelium. No staining was detected on the ocular surface epithelium. The normal, healthy cornea demonstrated no significant ICAM-1 expression on any of the epithelial layers, similar to that previously reported. To the best of our knowledge, this is the first report of ICAM-1 expression on the corneal epithelium from a patient with VKC.
最近的报告显示，细胞间黏附分子-1（ICAM-1；CD54）在各种过敏性疾病和炎症状态下的上皮组织中均有表达，包括过敏性哮喘患者的支气管上皮、变应原特异性激发后变应性患者的结膜上皮以及排斥反应中的角膜移植片的角膜上皮。我们调查了一位春季角结膜炎（VKC）患者角膜上皮中ICAM-1的表达情况。对患病角膜进行免疫组织化学染色显示，角膜上皮有丰富的ICAM-1表达。免疫反应性ICAM-1似乎主要定位于角膜上皮基底层和中层细胞。眼表上皮未检测到染色。正常健康角膜的任何上皮层均未显示出明显的ICAM-1表达，这与先前报道的情况相似。据我们所知，这是首次报道VKC患者角膜上皮中有ICAM-1表达。
