在广泛使用鼻用莫匹罗星软膏后，耐甲氧西林金黄色葡萄球菌中莫匹罗星耐药性的产生。
Development of mupirocin resistance among methicillin-resistant Staphylococcus aureus after widespread use of nasal mupirocin ointment.
作者信息
Miller M A, Dascal A, Portnoy J, Mendelson J
机构信息
Department of Microbiology, SMBD-Jewish General Hospital, Montreal, Quebec, Canada.
出版信息
Infect Control Hosp Epidemiol. 1996 Dec;17(12):811-3. doi: 10.1086/647242.
All methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from colonized or infected patients in a 625-bed public teaching hospital during an epidemic, and for 3 years thereafter, underwent susceptibility testing to mupirocin. Mupirocin resistance among MRSA increased markedly over this period (1990, 2.7%; 1991, 8.0%; 1992, 61.5%; 1993, 65%) in association with increased use of mupirocin ointment as an adjunct to infection control measures.
在一次流行期间以及此后3年，从一家拥有625张床位的公立教学医院的定植或感染患者中分离出的所有耐甲氧西林金黄色葡萄球菌（MRSA）菌株，都接受了对莫匹罗星的药敏试验。在此期间，MRSA对莫匹罗星的耐药性显著增加（1990年为2.7%；1991年为8.0%；1992年为61.5%；1993年为65%），这与莫匹罗星软膏作为感染控制措施辅助药物的使用增加有关。
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