Anderson G J
Liver Unit, Queensland Institute of Medical Research, Brisbane, Australia.
J Gastroenterol Hepatol. 1996 Nov;11(11):1030-2. doi: 10.1111/j.1440-1746.1996.tb00029.x.
Intestinal iron absorption plays an essential role in body iron homeostasis, although the mechanism by which iron moves across the cells of the intestinal epithelium and the way in which this process is regulated are poorly understood. Signals to alter iron absorption are received from the body by cells of the intestinal crypt and these signals are translated into an absorption response after the cells have migrated up the villus and differentiated into mature absorptive enterocytes. The intracellular iron concentration of the crypt cell may play an important role in the regulation of this process. Biochemical investigations on the mechanism of iron absorption have met with only limited success and a molecular understanding of this mechanism appears most likely to come from the identification of the genes affected in various inherited disturbances of iron absorption in several mammalian species.
肠道铁吸收在机体铁稳态中起着至关重要的作用，尽管铁穿过肠道上皮细胞的机制以及该过程的调节方式仍知之甚少。肠道隐窝细胞从机体接收改变铁吸收的信号，这些信号在细胞向上迁移至绒毛并分化为成熟的吸收性肠上皮细胞后转化为吸收反应。隐窝细胞的细胞内铁浓度可能在这一过程的调节中发挥重要作用。关于铁吸收机制的生化研究仅取得了有限的成功，对这一机制的分子理解似乎最有可能来自对几种哺乳动物物种各种遗传性铁吸收障碍中受影响基因的鉴定。
