Tucker J, Harding A E, Jahanshahi M, Nixon P D, Rushworth M, Quinn N P, Thompson P D, Passingham R E
Department of Experimental Psychology, University of Oxford, England.
Behav Neurosci. 1996 Dec;110(6):1229-34. doi: 10.1037//0735-7044.110.6.1229.
It has been claimed that patients with cerebellar pathology are impaired at associative learning. Patients with cerebellar ataxia (n = 7) were taught a visual-motor associative task. The task was chosen so as to allow comparisons with data currently being collected on the effects of cerebellar lesions on associative learning in monkeys. As a group the patients were as impaired at learning the task as a group of 8 patients with Huntington's disease. When each patient was individually matched with a control of the same age and IQ, some patients with cerebellar ataxia were found to be clearly impaired, but 2 were not. Of the 4 patients who were most clearly impaired, 2 had brainstem pathology and 2 did not. The relevance of these findings is discussed in relation to views concerning the functions of the cerebellum.
据称，患有小脑病变的患者在联想学习方面存在障碍。对7名小脑性共济失调患者进行了一项视觉运动联想任务的训练。选择该任务是为了能够与目前正在收集的关于小脑损伤对猴子联想学习影响的数据进行比较。作为一个群体，这些患者在学习该任务时与一组8名亨廷顿舞蹈症患者一样受损。当将每位患者与年龄和智商相同的对照组进行个体匹配时，发现一些小脑性共济失调患者明显受损，但有2名患者未受损。在4名受损最明显的患者中，2名有脑干病变，2名没有。结合有关小脑功能的观点对这些发现的相关性进行了讨论。
