Kodama M, Kodama T, Murakami M
Kodama Research Institute of Preventive Medicine, Nagoya, Japan.
In Vivo. 1996 Nov-Dec;10(6):575-84.
A series of publications from our laboratory have indicated that the practice of megadose vitamin C drip infusion treatment enhanced the activity of endogenous glucocorticoids in such a way as to improve the clinical course of allergy and autoimmune disease-a disease entity that is known to respond to the therapeutic effect of glucocorticoids. The present paper represents an extention of our vitamin C studies, and intends to investigate the problem whether or not chronic fatigue syndrome (CFS), an acquired immunodeficiency disease, can also be counted as one of the candidate diseases for the vitamin C infusion treatment. We prepared two kinds of vitamin C infusion sets for the clinical use: the dehydroepiandrosterone-annexed vitamin C infusion set (the new set) and the annex-free vitamin C infusion set (the old set). The new set was expected to enhance the endogenous activities of both glucocorticoids and gonadal steroids. We followed the clinical course of a male CFS patient using the old and new vitamin C infusion sets, and with and without the oral intake of erythromycin and chloramphenico. Results obtained are as follows: a) the observation period of a study subject covered a period of August 1995 to May 1996. Combination of pneumonia signs and dermatomyositis signs marked the onset of his CFS. b) Old infusion treatment together with the short term antibiotics treatment was found effective for the control of pneumonia in the first stage of the disease (from August to October, 1995). c) Signs of pneumonia recurrence gradually became eminent in the second stage of disease (from November, 1995, to January, 1996) in spite of the moderate frequency of the old treatment together with stepwise prolongation of the antibiotics treatment. d) The alternate practice of the old and new infusion treatments together with the long-term antibiotics treatment, as conducted in the 3rd stage of disease (from February to May, 1996) led to substantial extinction of pneumonia signs (leucocytosis, tachycardia etc). e) The practice of the new infusion treatment markedly increased the excretion of both 17-ketosteroids and 17-hydroxycorticosteroids in the urine. Evidence was also available to indicate that the dehydroepiandrosterone annex was converted to testosterone, which in turn made a contribution to the control of CFS. f) The immunological survey of lymphocyte subsets including NK cell percent failed to find a coherent change in a study subject with CFS. In conclusion, the above results could be taken as evidence to indicate that the new vitamin C infusion treatment effectuates the clinical control of CFS by fortifying the endogenous activities of both cortisol and testosterone. The significance of parallelism between pulmonary infection and CFS, as observed in the clinical course of the test subject, was discussed in the light of the focal infection theory of nephritis.
我们实验室的一系列出版物表明，大剂量维生素C静脉滴注治疗可增强内源性糖皮质激素的活性，从而改善过敏和自身免疫性疾病的临床进程——已知该疾病实体对糖皮质激素的治疗效果有反应。本文是我们维生素C研究的扩展，旨在探讨慢性疲劳综合征（CFS）这种获得性免疫缺陷疾病是否也可被视为维生素C静脉滴注治疗的候选疾病之一。我们制备了两种用于临床的维生素C静脉滴注装置：附脱氢表雄酮的维生素C静脉滴注装置（新装置）和无附加物的维生素C静脉滴注装置（旧装置）。新装置有望增强糖皮质激素和性腺类固醇的内源性活性。我们使用旧的和新的维生素C静脉滴注装置，以及在有和没有口服红霉素和氯霉素的情况下，跟踪了一名男性CFS患者的临床进程。获得的结果如下：a）一名研究对象的观察期为1995年8月至1996年5月。肺炎体征和皮肌炎体征的结合标志着他CFS的发作。b）发现旧的静脉滴注治疗与短期抗生素治疗相结合对疾病第一阶段（1995年8月至10月）的肺炎控制有效。c）尽管旧治疗频率适中且抗生素治疗逐步延长，但在疾病第二阶段（1995年11月至1996年1月），肺炎复发的体征逐渐变得明显。d）在疾病第三阶段（1996年2月至5月）进行的旧的和新的静脉滴注治疗交替进行以及长期抗生素治疗导致肺炎体征（白细胞增多、心动过速等）大幅消退。e）新的静脉滴注治疗显著增加了尿中17-酮类固醇和17-羟皮质类固醇的排泄。也有证据表明脱氢表雄酮附件转化为睾酮，这反过来有助于控制CFS。f）对包括NK细胞百分比在内的淋巴细胞亚群的免疫学调查未能在一名CFS研究对象中发现一致的变化。总之，上述结果可作为证据表明，新的维生素C静脉滴注治疗通过增强皮质醇和睾酮的内源性活性实现了对CFS的临床控制。根据肾炎的病灶感染理论，讨论了在受试对象临床进程中观察到的肺部感染与CFS之间平行关系的意义。
