Kalogeraki A, Tamiolakis D, Tzardi M, Datseris G, Karvelas K, Kanavaros P, Delides G
Department of Pathology University Hospital of Heraklion, Crete, Greece.
In Vivo. 1996 Nov-Dec;10(6):613-6.
Cervical intraepithelial lesions were diagnosed cytologically, and confirmed histologically in 328 patients from 1990 to 1996 at the University Hospital of Heraklion. The women were grouped according to the grade of the cervical intraepithelial lesion as low grade cases (LSIL) on high grade cases (HSIL) (Bethesda classification). They were also grouped according to their smoking status as non-smokers or smokers. A very strong statistically significant difference (p < 0.0001) in the incidence of the disease between non-smokers and smokers was found, to the disadvantage of smokers. Also a very statistically significant (p approximately 0.001) association was found between the number of cigarettes per day, duration of exposure (years of use) and the grade of cervical intraepithelial lesion. Our results indicate that cigarette smoking is a risk factor in the development of cervical intraepithelial lesions and possibly cervical squamous cancer. Further studies are required to prove this hypothesis and to document the biological plausibility of this relationship.
1990年至1996年期间，在伊拉克利翁大学医院对328例患者进行了宫颈上皮内病变的细胞学诊断，并经组织学确诊。根据宫颈上皮内病变的级别，将这些女性分为低级别病例（低度鳞状上皮内病变，LSIL）和高级别病例（高度鳞状上皮内病变，HSIL）（贝塞斯达分类法）。她们还根据吸烟状况分为非吸烟者或吸烟者。结果发现，非吸烟者和吸烟者之间疾病发病率存在非常显著的统计学差异（p < 0.0001），吸烟者处于劣势。此外，还发现每日吸烟量、暴露持续时间（吸烟年限）与宫颈上皮内病变级别之间存在非常显著的统计学关联（p约为0.001）。我们的结果表明，吸烟是宫颈上皮内病变乃至可能的宫颈鳞状癌发生的一个危险因素。需要进一步研究来证实这一假设，并证明这种关系的生物学合理性。
