Walton L J, Thornhill M H, Farthing P M
Department of Oral Pathology, St Bartholomew's and the Royal London School of Medicine and Dentistry, England.
J Oral Pathol Med. 1996 Nov;25(10):534-7. doi: 10.1111/j.1600-0714.1996.tb01727.x.
The distribution of T lymphocytes expressing the alpha beta or gamma delta heterodimer of the T cell receptor (TCR) was examined in normal oral mucosa (NOM) and reticular oral lichen planus (OLP) using a panel of antibodies specific for CD3, the alpha beta TCR and the gamma delta TCR. Intra-epithelial lymphocytes were counted and epithelial surface length was measured by image analysis. T cells in the lamina propria were not quantified. Total intra-epithelial lymphocytes were increased in OLP compared with NOM (P = 0.0004). The proportions of cells expressing the gamma delta TCR in NOM and OLP were 10% and 9.3%, respectively, suggesting there is no selective recruitment from the circulation of either alpha beta or gamma delta TCR-bearing cells into normal oral epithelium or that affected by OLP. The role, if any, of gamma delta T cells in the pathogenesis of OLP remains to be determined.
利用一组针对CD3、αβT细胞受体（TCR）和γδTCR的特异性抗体，在正常口腔黏膜（NOM）和网状口腔扁平苔藓（OLP）中检测表达T细胞受体（TCR）αβ或γδ异二聚体的T淋巴细胞分布。通过图像分析对上皮内淋巴细胞进行计数并测量上皮表面长度。未对固有层中的T细胞进行定量分析。与NOM相比，OLP中的上皮内淋巴细胞总数增加（P = 0.0004）。NOM和OLP中表达γδTCR的细胞比例分别为10%和9.3%，这表明不存在从循环中选择性募集携带αβ或γδTCR的细胞进入正常口腔上皮或受OLP影响的上皮的情况。γδT细胞在OLP发病机制中的作用（如果有）仍有待确定。
