Little B B, Wilson G N, Jackson G
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75235-9032, USA.
Teratology. 1996 Sep;54(3):145-9. doi: 10.1002/(SICI)1096-9926(199609)54:3<145::AID-TERA4>3.0.CO;2-2.
It was suggested that a "fetal cocaine syndrome" exists. The objective of this study was to systematically investigate whether or not a "cocaine syndrome" exists. The setting was Parkland Memorial Hospital, a large urban public hospital in Dallas, TX, where approximately 15,000 infants are delivered annually. Infants who tested positive by urinalysis for cocaine (n = 25) were included in this study. Controls negative for cocaine (n = 25) were matched to cocaine-exposed infants for estimated gestational age, sex, and race. A standardized dysmorphology examination (135 features) and a series of anthropometric measures (n = 22) were done for each cocaine-exposed and control infant by an observer blinded to drug-exposure status. Fetal growth retardation characterized cocaine-exposed infants. No characteristic pattern of minor dysmorphic or anthropometric features of the face, limbs, or torso was observed among cocaine-exposed infants. Cocaine-exposed infants lack a facial gestalt or torso/limb features that would characterize a syndrome. If a "cocaine syndrome" that can be characterized dysmorphologically and/or anthropometrically exists, its occurrence seems infrequent.
有人提出存在“胎儿可卡因综合征”。本研究的目的是系统调查是否存在“可卡因综合征”。研究地点是得克萨斯州达拉斯市的一家大型城市公立医院帕克兰纪念医院，该医院每年约有15000名婴儿出生。本研究纳入了尿样可卡因检测呈阳性的婴儿（n = 25）。可卡因检测呈阴性的对照组婴儿（n = 25）在估计孕周、性别和种族方面与暴露于可卡因的婴儿进行匹配。由对药物暴露状况不知情的观察者对每一名暴露于可卡因的婴儿和对照婴儿进行标准化的畸形学检查（135项特征）和一系列人体测量（n = 22）。胎儿生长迟缓是暴露于可卡因婴儿的特征。在暴露于可卡因的婴儿中，未观察到面部、四肢或躯干的轻微畸形或人体测量特征的特征性模式。暴露于可卡因的婴儿缺乏可表征一种综合征的面部形态或躯干/四肢特征。如果存在一种可通过畸形学和/或人体测量学表征的“可卡因综合征”，其发生率似乎很低。
