Feig L A, Urano T, Cantor S
Department of Biochemistry, Sackler School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.
Trends Biochem Sci. 1996 Nov;21(11):438-41. doi: 10.1016/s0968-0004(96)10058-x.
It is becoming clear that Ras proteins mediate their diverse biological functions by binding to, and participating in, the activation of multiple downstream targets. Recent work has identified nucleotide-exchange factors for Ral-GTPases as the newest members of the set of putative Ras 'effector molecules'. This new work has also detected two potential downstream targets of Ral proteins, a novel CDC42/Rac GTPase-activating protein and a phospholipase D.
越来越清楚的是，Ras蛋白通过结合并参与多个下游靶点的激活来介导其多样的生物学功能。最近的研究已将Ral-GTPases的核苷酸交换因子鉴定为假定的Ras“效应分子”集合中的最新成员。这项新研究还检测到Ral蛋白的两个潜在下游靶点，一种新型的CDC42/Rac GTPase激活蛋白和一种磷脂酶D。
