Ouzounis C, Casari G, Sander C, Tamames J, Valencia A
Artificial Intelligence Center, SRI International, Menlo Park, CA 94025, USA.
Trends Biotechnol. 1996 Aug;14(8):280-5. doi: 10.1016/0167-7799(96)10043-3.
Complete genomes from model organisms provide new challenges for computational molecular biology. Novel questions emerge from the genome data obtained from the functional prediction of thousands of gene products. In this review, we present some approaches to the computational comparison of genomes, based on sequence and text analysis, and comparisons of genome composition and gene order.
模式生物的完整基因组给计算分子生物学带来了新的挑战。从数千种基因产物的功能预测中获得的基因组数据引发了新的问题。在这篇综述中,我们介绍了一些基于序列和文本分析以及基因组组成和基因顺序比较的基因组计算比较方法。