喂食色氨酸限制饮食对大鼠色氨酸向烟酸转化率的影响。
Effects of feeding tryptophan-limiting diets on the conversion ratio of tryptophan to niacin in rats.
作者信息
Shibata K, Shimada H, Kondo T
机构信息
Department of Human Health Science, Faculty of Human Sciences, Osaka International University for Women, Japan.
出版信息
Biosci Biotechnol Biochem. 1996 Oct;60(10):1660-6. doi: 10.1271/bbb.60.1660.
We investigated the effects of feeding various types of nicotinic acid-free, tryptophan-limiting diets on the conversion ratio of tryptophan to niacin in rats. Various tryptophan-limiting diets were made by adding zein, gelatin, glycine, threonine, methionine, or glycine + threonine + methionine to a nicotinic acid-free, 9% casein diet. When the rats were fed with the tryptophan-limiting diets, the conversion ratio of tryptophan to niacin was markedly decreased. However, the ratio recovered after the addition of tryptophan to the tryptophan-limiting diets. These results clearly prove that the conversion was lowest when the rats were fed with the tryptophan-limiting diets. Therefore, we think that the pellagragenic factor of corn is simply due to a low content of tryptophan, but the adverse effect is due to a low conversion ratio of tryptophan to niacin.
我们研究了给大鼠喂食各种无烟酸、色氨酸受限的日粮对色氨酸向烟酸转化率的影响。通过向无烟酸、9%酪蛋白日粮中添加玉米醇溶蛋白、明胶、甘氨酸、苏氨酸、蛋氨酸或甘氨酸+苏氨酸+蛋氨酸来制备各种色氨酸受限日粮。当给大鼠喂食色氨酸受限日粮时，色氨酸向烟酸的转化率显著降低。然而，在色氨酸受限日粮中添加色氨酸后，该转化率得以恢复。这些结果清楚地证明，当给大鼠喂食色氨酸受限日粮时，转化率最低。因此，我们认为玉米的致糙皮病因素仅仅是由于色氨酸含量低，但不良影响是由于色氨酸向烟酸的转化率低。
Zotero 插件