Shibata Katsumi, Imai Eri, Sano Mitsue, Fukuwatari Tsutomu
Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan.
Biosci Biotechnol Biochem. 2012;76(1):186-8. doi: 10.1271/bbb.110564. Epub 2012 Jan 7.
Weaning rats were fed a niacin-free 20% casein diet. Twenty-four-h-urine samples were collected, and nicotinamide and its catabolites were measured. A correlation was found between the urinary excretory ratio of nicotinamide catabolites (N(1)-methyl-2-pyridone-5-carboxamide + N(1)-methyl-4-pyridone-3-carboxamide)/N(1)-methylnicotinamide and the tryptophan-nicotinamide conversion ratio during growing period of the rats. This indicates the possibility that the conversion ratio can be deduced from the excretory ratio.
给断乳大鼠喂食不含烟酸的20%酪蛋白饮食。收集24小时尿液样本，并测定烟酰胺及其代谢产物。在大鼠生长期间，发现烟酰胺代谢产物（N(1)-甲基-2-吡啶酮-5-甲酰胺 + N(1)-甲基-4-吡啶酮-3-甲酰胺）/N(1)-甲基烟酰胺的尿排泄率与色氨酸-烟酰胺转化率之间存在相关性。这表明从排泄率推断转化率是有可能的。
