Ju H R, Wu H Y, Nishizono S, Sakono M, Ikeda I, Sugano M, Imaizumi K
Laboratory of Nutrition Chemistry, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
Biosci Biotechnol Biochem. 1996 Nov;60(11):1856-60. doi: 10.1271/bbb.60.1856.
Brown Norway rats were primed intraperitoneally with beta-lactoglobulin for 3 wk to induce reaginic antibody, during which time they were fed diets containing 10% each of coconut oil (CO), high oleic safflower oil, safflower oil (SO), or fish oil, then they were challenged for 3 h orally with the antigen. The dietary SO, compared to other dietary fats, resulted in lower circulatory release of rat chymaseII (RChyII), an indicator of degranulation of mucosal mast cells in the intestine, in response to the antigen. Addition of 0.5% curcumin to the CO or SO diet lowered the release. The SO diet, compared to CO diet, tended to increase the concentration of reaginic antibody, but the influence of curcumin addition was not prominent. These results indicate that dietary ingredients differently influence the synthesis of immunoglobulin E and degranulation of mast cells.
用β-乳球蛋白对棕色挪威大鼠进行腹腔注射致敏3周以诱导反应素抗体，在此期间，给它们喂食分别含有10%椰子油（CO）、高油酸红花油、红花油（SO）或鱼油的日粮，然后用抗原对它们进行3小时的口服激发。与其他膳食脂肪相比，日粮中的SO导致大鼠糜蛋白酶II（RChyII）的循环释放降低，RChyII是肠道黏膜肥大细胞脱颗粒的一个指标，是对抗原的反应。在CO或SO日粮中添加0.5%的姜黄素可降低释放。与CO日粮相比，SO日粮倾向于增加反应素抗体的浓度，但添加姜黄素的影响并不显著。这些结果表明，膳食成分对免疫球蛋白E的合成和肥大细胞的脱颗粒有不同的影响。
