Critical Care Department, "Sotiria" General Hospital of Chest Diseases, 152 Mesogeion Avenue, 11527 Athens, Greece.
Department of Clinical Nutrition, Evangelismos General Hospital of Athens, Ypsilantou 45-47, 10676 Athens, Greece.
Nutrients. 2021 Sep 29;13(10):3458. doi: 10.3390/nu13103458.
There is an ongoing need for new therapeutic modalities against SARS-CoV-2 infection. Mast cell histamine has been implicated in the pathophysiology of COVID-19 as a regulator of proinflammatory, fibrotic, and thrombogenic processes. Consequently, mast cell histamine and its receptors represent promising pharmacological targets. At the same time, nutritional modulation of immune system function has been proposed and is being investigated for the prevention of COVID-19 or as an adjunctive strategy combined with conventional therapy. Several studies indicate that several immunonutrients can regulate mast cell activity to reduce the de novo synthesis and/or release of histamine and other mediators that are considered to mediate, at least in part, the complex pathophysiology present in COVID-19. This review summarizes the effects on mast cell histamine of common immunonutrients that have been investigated for use in COVID-19.
目前仍需要针对 SARS-CoV-2 感染的新治疗方法。肥大细胞组胺被认为与 COVID-19 的病理生理学有关，是促炎、纤维化和血栓形成过程的调节剂。因此，肥大细胞组胺及其受体代表了有前途的药理学靶点。与此同时，人们提出了通过营养调节免疫系统功能来预防 COVID-19，或作为联合常规治疗的辅助策略，并正在对此进行研究。几项研究表明，几种免疫营养素可以调节肥大细胞的活性，以减少新合成和/或释放被认为至少部分介导 COVID-19 中复杂病理生理学的组胺和其他介质。这篇综述总结了已在 COVID-19 中研究过的常见免疫营养素对肥大细胞组胺的影响。
Zotero 插件