Kuhl C K, Bieling H, Gieseke J, Ebel T, Mielcarek P, Far F, Folkers P, Elevelt A, Schild H H
Department of Radiology, University of Bonn, Germany.
Radiology. 1997 Jan;202(1):87-95. doi: 10.1148/radiology.202.1.8988196.
To evaluate the differentiation of benign from malignant breast tumors with T2*-weighted perfusion magnetic resonance (MR) imaging (blood volume imaging) versus that with dynamic T1-weighted contrast agent-enhanced MR imaging.
Ten healthy adult volunteers and 18 adult patients with benign or malignant lesions underwent both conventional T1-weighted dynamic contrast-enhanced breast MR imaging and repetitive first-pass, single-section, dynamic T2*-weighted perfusion MR imaging. Images were obtained before, during, and after injection of 20 mL of gadopentetate dimeglumine; peak gadopentetate dimeglumine concentrations were calculated from the maximal signal intensity loss on T2*-weighted images.
No perfusion effect was detectable in healthy breast parenchyma. A strong susceptibility-mediated signal intensity loss occurred in malignant breast tumors. No or only minor perfusion effects were seen in fibroadenomas, in spite of their rapid enhancement at T1-weighted dynamic imaging. Perfusion imaging was possible after conventional dynamic contrast-enhanced breast MR imaging.
T2*-weighted perfusion imaging exploits the susceptibility-mediated signal intensity loss of a first-pass bolus of gadopentetate dimeglumine within the capillary bed. First-pass perfusion imaging of breast lesions is feasible. It is promising in the differentiation of benign from malignant, rapidly enhancing lesions.
比较T2*加权灌注磁共振成像（血容量成像）与动态T1加权对比剂增强磁共振成像对乳腺良恶性肿瘤的鉴别能力。
10名健康成年志愿者和18名患有良性或恶性病变的成年患者接受了常规T1加权动态对比增强乳腺磁共振成像以及重复的首次通过、单层面、动态T2加权灌注磁共振成像。在注射20 mL钆喷酸葡胺之前、期间和之后获取图像；根据T2加权图像上的最大信号强度损失计算钆喷酸葡胺的峰值浓度。
在健康乳腺实质中未检测到灌注效应。在恶性乳腺肿瘤中出现了强烈的由磁化率介导的信号强度损失。尽管纤维腺瘤在T1加权动态成像中快速强化，但在其中未见或仅见轻微的灌注效应。在常规动态对比增强乳腺磁共振成像后可以进行灌注成像。
T2*加权灌注成像利用了钆喷酸葡胺首次通过时在毛细血管床内由磁化率介导的信号强度损失。乳腺病变的首次通过灌注成像是可行的。在鉴别良恶性快速强化病变方面很有前景。
