白细胞介素1β诱导的眼部炎症期间的玻璃体变化

Vitreous changes during ocular inflammation induced by interleukin 1 beta.

作者信息

Hikichi T, Ueno N, Chakrabarti B, Trempe C L

机构信息

Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, USA.

出版信息

Jpn J Ophthalmol. 1996;40(3):297-302.

PMID:8988418

Abstract

To determine the mechanisms of vitreous changes during ocular inflammation, we investigated these changes, focusing on the collagen, in an experimental model of ocular inflammation induced by intravitreal injection of interleukin 1 beta in rabbits. Inflammation caused gel contraction, with release of a watery liquid from the gel, and increases in the amount of insoluble material and high-molecular-weight components of the vitreous collagen, presumably due to extensive cross-links of the collagen molecules. The cross-links of vitreous collagen may promote vitreous gel contraction and the release of watery liquid from the gel.

摘要

为了确定眼部炎症期间玻璃体变化的机制，我们在兔眼玻璃体腔内注射白细胞介素1β诱导的眼部炎症实验模型中，研究了这些变化，重点关注胶原蛋白。炎症导致凝胶收缩，凝胶中释放出水样液体，玻璃体胶原蛋白的不溶性物质和高分子量成分增加，这可能是由于胶原蛋白分子广泛交联所致。玻璃体胶原蛋白的交联可能促进玻璃体凝胶收缩以及凝胶中水样液体的释放。