Davis G, Johns E J
Department of Physiology, Medical School, University of Birmingham, UK.
J Auton Nerv Syst. 1996 Dec 14;61(3):209-17. doi: 10.1016/s0165-1838(96)00092-6.
In chloralose/urethane anaesthetised stroke-prone spontaneously hypertensive rats, blood pressure and integrated renal nerve activity were higher whereas heart rate was lower than in Wistar rats by 37, 146 and 11%, respectively (all P < 0.001). The renal nerve signal was subjected to fast Fourier transformation to generate power spectra. In the hypertensive rats, total spectral power was 400% (P < 0.01) and power at the heart rate frequency was 50% (P < 0.01) greater while phase and time differences were shorter (both P < 0.001) than in Wistar rats. Brachial nerve stimulation increased total power in Wistar and hypertensive rats (P < 0.05), but importantly, power at the heart rate frequency was decreased by 80% in Wistar whereas there was a 20% (P < 0.05) increase in hypertensive rats, while phase and time differences were raised only in hypertensive rats (P < 0.05). Bilateral cervical vagotomy of the hypertensive rats had minimal actions on most variables but phase and time differences were doubled compared to intact hypertensive animals, but brachial nerve stimulation decreased power at the heart rate frequency (P < 0.05) which was a very different response from intact rats. Resting blood pressure, heart rate, total power and power at the heart rate frequency in the carotid sinus denervated animals were lower than in intact hypertensive rats, between 17 and 71%, respectively, but increased during brachial nerve stimulation. These experiments demonstrated that whereas somatic sensory input can modulate the pattern of sympathetic nerve activity to the kidney under normal conditions, this does not occur in the hypertensive rat. This appears to be related to afferent information carried by the vagus which suppresses the normal response; the carotid sinus baroreceptors are devoted to organising the nerve activity in relation to the blood pressure pulse wave.
在水合氯醛/乌拉坦麻醉的易中风自发性高血压大鼠中，血压和肾神经活动积分高于Wistar大鼠，而心率比Wistar大鼠低37%、146%和11%（均P<0.001）。对肾神经信号进行快速傅里叶变换以生成功率谱。与Wistar大鼠相比，高血压大鼠的总频谱功率高400%（P<0.01），心率频率处的功率高50%（P<0.01），而相位和时间差更短（均P<0.001）。臂神经刺激使Wistar大鼠和高血压大鼠的总功率增加（P<0.05），但重要的是，Wistar大鼠心率频率处的功率降低了80%，而高血压大鼠增加了20%（P<0.05），且相位和时间差仅在高血压大鼠中增加（P<0.05）。高血压大鼠双侧颈迷走神经切断术对大多数变量的影响最小，但与完整的高血压动物相比，相位和时间差增加了一倍，但臂神经刺激使心率频率处的功率降低（P<0.05），这与完整大鼠的反应非常不同。颈动脉窦去神经动物的静息血压、心率、总功率和心率频率处的功率分别比完整的高血压大鼠低17%至71%，但在臂神经刺激时增加。这些实验表明，在正常情况下，躯体感觉输入可以调节肾交感神经活动模式，但在高血压大鼠中则不会。这似乎与迷走神经携带的传入信息有关，该信息抑制了正常反应；颈动脉窦压力感受器致力于组织与血压脉搏波相关的神经活动。
